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Abstract #4084

Free-Breathing Dynamic Contrast Enhanced Compressed-Sensing Imaging for Reliable Estimation of Liver Perfusion

Hersh Chandarana1, Kai Tobias Block1, Henry Rusinek1, Matthew B. Greenberg1, Li Feng2, Daniel K. Sodickson1, Ricardo Otazo1

1Radiology; Center for Biomedical Imaging, NYU Langone Medical Center, New York, NY, United States; 2Radiology; Center for Biomedical Imaging, New York University Langone Medical Center, New York, NY, United States

Studies have shown the utility of perfusion weighted MR imaging in diagnosis of liver fibrosis and assessment of portal hypertension. Here we performed free-breathing high spatial and temporal resolution liver imaging with compressed sensing technique called GRASP. GRASP data was reconstructed with temporal resolution of 3 seconds and processed with dual-input single compartment model to generate perfusion metrics, which were significantly different in cirrhotics compared to healthy subjects. Advantages over Cartesian scheme are higher resolution, motion robustness eliminating need for labor-intensive registration, and generating dynamic perfusion data from routine clinical exam, hence eliminating need for additional contrast dose or acquisition time.