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Abstract #4219

ParaCEST: Imaging pH with High eff Ln(III) Complexes on a 1T Permanent Magnet.

Giaime Rancan1, Daniela Delli Castelli2, Silvio Aime3, 4

1Technische Universitt Mnchen, Mnchen, Bayern, Germany; 2University of Torino, Torino, Piemonte, Italy; 3Universit di Torino, Torino, Piemonte, Italy; 4Institute for Advanced Study, Technische Universitt Mnchen, Garching, Bayern, Germany

Lanthanide-HPDO3A chelates are stable and safe compounds, some of which apt for contrast agent mediated ParaCEST imaging. In this work we observe some promising candidates for functional CEST ratiometrical analyses and determine their suitability for studies at 1T field strength. An in vivo proof of concept study was performed to further investigate this methodology. The use of entry level MRI instrumentation will expand the scope of ParaCEST techniques.