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Abstract #4220

Iopamidol CEST for PH Measurements on a Clinical 3T Scanner: Phantom and First Human in vivo Study

Anja Mller-Lutz1, Nadia Khalil1, Rotem S. Lanzman1, Georg Oeltzschner1, Gael Pentang1, Vladimir Jellus2, Benjamin Schmitt2, Gerald Antoch1, Hans-Jrg Wittsack1

1University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, NRW, Germany; 2Siemens, Healthcare Sector, Imaging & Therapy Division, Erlangen, BY, Germany

Chemical exchange saturation transfer (CEST) imaging with the contrast agent Iopamidol enables pH determination in vitro and in vivo. However, in vivo pH determination with Iopamidol as CEST contrast agent was only performed in animals. Nevertheless, in vivo pH measurements in human with Iopamidol at clinical used MRI systems are desirable. The aim of this study was to assess the feasibility of pH measurements with Iopamidol CEST on clinical MRI systems (3T) by using a CEST presaturation module consisting of a pulse train of presaturation pulses in vitro and to perform a first in vivo measurement in a human subject.