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Abstract #4227

Biochemical MRI with GagCEST (Glycosaminoglycan Chemical Exchange Saturation Transfer Imaging) of Finger Joint Cartilage in Rheumatoid Arthritis

Anja Mller-Lutz1, Benedikt Ostendorf1, Christoph Schleich1, Nadia Khalil1, Benjamin Schmitt2, Vladimir Jellus2, Philipp Sewerin1, Axel Scherer1, Georg Oeltzschner1, Gael Pentang1, Matthias Schneider1, Gerald Antoch1, Hans-Jrg Wittsack1, Falk Miese1

1University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Dusseldorf, NRW, Germany; 2Siemens, Healthcare Sector, Imaging & Therapy Division, Erlangen, BY, Germany

MRI plays an increasing role in the diagnosis and treatment monitoring of arthritis. Next to synovitis, erosions and osteoedema, cartilage composition is of increasing importance in the research of arthritis. gagCEST has recently been demonstrated to be sensitive to alterations in the biochemical composition of cartilage in the knee in patients following cartilage repair surgery as well as in vertebral disks. Our work shows the feasibility of gagCEST imaging in finger joint cartilage in healthy volunteers and patients with rheumatoid arthritis.