Abstract #4277

3D Mapping of T2* and B0 Inhomogeneities for Water/Fat Separation

Abraam S. Soliman¹,², Jing Yuan², Terry M. Peters¹,², Charles A. McKenzie¹,³

¹Biomedical Engineering, University of Western Ontario, London, Ontario, Canada; ²Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; ³Medical Biophysics, University of Western Ontario, London, Ontario, Canada

Several confounding factors can compromise the ability of MRI to accurately quantify fat, particularly B0 inhomogeneities and T2* decay. Recently, a labeling approach has been proposed to estimate B0 field variations in fat/water separation and was shown to outperform the widely-used region growing method. In this work, we extend this technique to 3D as well as integrate pixel-by-pixel calculation of T2* decay, necessary for accurate fat quantification. We demonstrate our approach on data for healthy volunteers and NAFLD patients.