Ultrafast High-Resolution NMR Spectroscopy Through Indirect Zero-Quantum Coherence Detection in Inhomogeneous Fields

Hanping Ke¹, Hao Chen¹, Zhiyong Zhang¹, Yanqin Lin¹, Zhong Chen¹, Shuhui Cai¹

In some cases, high-resolution NMR spectra are virtually impossible to obtain by conventional NMR methods because of intrinsic or extrinsic field inhomogeneity. In this study, spatial encoding intramolecular zero-quantum coherence (ZQC) technique was proposed to ultrafast achieve high-resolution NMR spectra under inhomogeneous fields. Theoretical analyses and experimental observations demonstrate that high-resolution NMR spectral information can be revived with two scans even when the field inhomogeneities are severe enough to erase most spectral information. This work may provide a new way to extremely enhance the acquisition efficiency of ZQC high-resolution spectroscopy for in vivo study of metabolites in organisms.