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Abstract #4482

Full-Cycle Cine DENSE for Assessment of Systolic and Diastolic Myocardial Function

Bhairav B. Mehta1, Andrew D. Gilliam2, Michael Salerno1, 3, Frederick H. Epstein1, 4

1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2A.D. Gilliam Consulting, Providence, RI, United States; 3Department of Medicine, Cardiology Division University of Virginia, Charlottesville, VA, United States; 4Department of Radiology, University of Virginia, Charlottesville, VA, United States

Heart failure with preserved ejection fraction (HF-PEF) accounts for more than half of all the heart failure cases. Quantification of diastolic function is becoming as important as quantification of systolic function. Echocardiography is commonly used to assess diastolic function but has limitations affecting its measurement accuracy. Strain and strain rate measurement using cine DENSE MRI has advantages over echocardiographic techniques and could improve the diagnosis of diastolic dysfunction. Previous cine DENSE sequences have primarily imaged systole. Here we modified a cine DENSE sequence to image entire cardiac cycle with sufficient SNR to compute accurate systolic and diastolic displacements, strains, and strain rates.