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Abstract #4511

Investigation of Cardiac Malate-Aspartate Shuttle at High Workload Using Hyperpolarized [1,2-13C2]pyruvate

Albert P. Chen1, Angus Z. Lau2, 3, Yi-ping Gu2, Marie A. Schroeder4, Jennifer Barry5, Charles H. Cunningham2, 3

1GE Healthcare, Toronto, ON, Canada; 2Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 3Dept. of Medical Biophysics , University of Toronto, Toronto, ON, Canada; 4Dept. of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; 5Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada

This study demonstrated that changes in α-ketoglutarate derived glutamate could be monitored non-invasively and independently from PDC flux using hyperpolarized [1,2-13C2]pyruvate at different cardiac workloads. A reduction in the glutamate to bicarbonate ratio may indicate a limited transport of reducing equivalent across mitochondria membrane via malate-aspartate shuttle at high cardiac workload.