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Abstract #4517

Novel Detection of Intramyocardial Hemorrhage Following Acute Myocardial Infarction by T2 Mapping

Nilesh R. Ghugre1, 2, Venkat Ramanan1, Mihaela Pop1, Jennifer Barry1, Kim A. Connelly3, Graham A. Wright1, 2

1Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Division of Cardiology, St. Michaels Hospital, Toronto, ON, Canada

T2 mapping techniques [M=M0.exp(-t/T2)] can detect the occurrence of hemorrhage after acute myocardial infarction but can be confounded by opposing effects from edema. We hypothesized that the M0 term may provide additional information beyond T2 for identifying the hemorrhagic sites. The study involved a porcine model (N=6) with imaging at day 2 post-infarction. Hemorrhagic sites could not be distinctly identified on T2 maps, however M0 maps demonstrated signal voids that were spatially correlated with those identified as hemorrhage on T2* maps. T2 and M0 maps together provide complementary information that may potentially be valuable in simultaneously characterizing both the inflammatory and hemorrhagic state of tissue post-AMI.