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Abstract #4524

MRI Perfusion Indices During the Evolution of Microembolized Myocardial Infarct

Maythem Saeed1, Jessica Murayama1, Carol Stillson1, Loi Do1, Steven W. Hetts2, Mark W. Wilson1

1Radiology and Biomedical Imaging, UC San Francisco, San Francisco, Ca, United States; 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States

The aims were to chronologically monitor and compare myocardial perfusion in swine subjected to infarct with and without coronary microemboli release. Gradient echo pulse sequences were used to monitor Gd-DTPA passage in LV and measure infarct size at 3 days and 5 weeks after interventions. Microemboli in pre-existing infarct induced progressive perfusion deficit, increased incidence of microvascular obstruction, and infarct size. MR indices of myocardial perfusion provide valuable information on the effects of coronary microemboli in pre-existing AMI and hypertrophied remote myocardium. The high sensitivity of MR perfusion makes it a powerful tool in evaluation of new distal filtration devices.