Abstract #0006
Reproducibility of 2-hydroxyglutarate spectroscopic imaging in IDH-mutated glioma patients at 3.0 T in vivo
Sandeep K Ganji 1,2 , Zhongxu An 1 , Akshay Madan 1 , Elizabeth A Maher 3,4 , and Changho Choi 1,2
1
Advanced Imaging Research Center, UT
Southwestern Medical Center, Dallas, TX, United States,
2
Radiology,
UT Southwestern Medical Center, Dallas, TX, United
States,
3
Department
of Internal Medicine, UT Southwestern Medical Center,
Dallas, TX, United States,
4
Harold
C. Simmons Cancer Center, UT Southwestern Medical
Center, Dallas, TX, United States
Recent studies have developed several techniques for
measurement of 2-hydroxyglutarate (2HG) levels in brain
gliomas and substantiate 2HG levels as a useful clinical
biomarker. However for transitioning these methods to
routine clinical use and obtain clinically significant
results requires rigorous validation and testing. The
purpose of this study was to perform repeated
measurement of 2HG levels in a group of glioma patients
and to determine intersession reproducibility, and
repeatability.
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