Abstract #0007
Increased Blood-Brain Barrier Leakage in Alzheimers Disease Detected with Dual Time-Resolution Dynamic Contrast Enhanced MRI
Harm J van de Haar 1 , Saartje Burgmans 1 , Matthias JP van Osch 2 , Jacobus FA Jansen 3 , Frank CG van Bussel 1 , Sau May Wong 1 , Martijn Wolters 3 , Ccile RLPN Jeukens 3 , Mark A van Buchem 2 , Paul AM Hofman 3 , Frans RJ Verhey 1 , and Walter H Backes 3
1
University of Maastricht, Maastricht,
Netherlands,
2
Leiden
University Medical Center, Leiden, Netherlands,
3
Maastricht
University Medical Center, Maastricht, Netherlands
Blood-brain barrier defects prior to neuronal damage are
a potential underlying mechanism for dementia. A
dual-temporal resolution Dynamic Contrast Enhanced (DCE)-MRI
protocol was used to detect differences in terms of
fractional plasma volume (vp) and BBB leakage (Ki) in
patients suffering from Alzheimers disease. The results
suggest significantly stronger leakage in normal
appearing white matter in the patients compared to the
healthy controls, which supports our hypothesis that BBB
leakage is increased in patients with (preclinical)
Alzheimers dementia. Longitudinal research is necessary
to reveal the exact relationship with Alzheimer
pathology and small vessel disease.
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