Abstract #0018
Accuracy and reliability of ASL perfusion in evaluating neurodegenerative disease: voxel-wise and cortical-regional comparison with 18F-FDG PET
Steve H Fung 1,2 , Christof Karmonik 1,2 , Mario F Dulay 1,2 , Belen Pascual 1,2 , Daniel Y Lee 1,2 , Stephen B Chiang 1,2 , Ronald E Fisher 1,2 , Robert G Grossman 1,2 , Bryan M Spann 1,2 , and Gustavo C Roman 1,2
1
Houston Methodist Research Institute,
Houston, Texas, United States,
2
Houston
Methodist Hospital, Houston, Texas, United States
Pattern of regional cerebral hypometabolism observed by
FDG-PET is well-established technique for diagnosing
Alzheimers disease as well as differentiation from
other causes of dementia. Recent studies using ASL have
shown similar diagnostic utility by observing regional
cerebral hypoperfusion pattern. We compared regional and
voxel-level CBF estimated from ASL to SUV from FDG-PET,
test-retest reliability of CBF from ASL, and CBF from
ASL in eyes-open versus eyes-closed states in patients
evaluated for neurodegenerative disease. Aside for
occipital lobe, we found good correlation between CBF on
ASL and SUV on FDG-PET, in agreement with previous
published studies. Due to discrepancy in the occipital
lobe, caution should be made in interpreting occipital
hypoperfusion with ASL, especially when considering
dementia with Lewy bodies or Parkinsons disease.
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