Application of multi-shell NODDI in Multiple Sclerosis
Torben Schneider 1 , Wallace Brownlee 1 , Hui Zhang 2 , Olga Ciccarelli 3 , David H Miller 1 , and Claudia A. M. Wheeler-Kingshott 1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
of Computer Science & Centre for Medical Image
Computing, UCL, London, United Kingdom,
of Brain Repair and Rehabilitation, UCL Institute of
Neurology, London, United Kingdom
Neurite orientation and dispersion and density imaging (NODDI)
is a new technique that promises unique insight into the
density and orientation dispersion of neuronal tissue.
In this pilot study we apply NODDI for the first time to
Multiple Sclerosis patients and compare with standard
DTI metrics. We show that NODDI detects and provides
more distinction of the microstructural disruption in
Multiple Sclerosis in both lesional tissue and normal
appearing white matter compared to healthy controls.
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