Abstract #0020
Diffusion Magnetic Resonance Monitors Intramyocellular Lipid Droplet Size In Vivo
Peng Cao 1,2 , Shu-Juan J. Fan 1,2 , Anna M. Wang 1,2 , Victor B. Xie 1,2 , Zhongwei Qiao 1,2 , Gary M. Brittenham 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Pokfulam, Hong
Kong, China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Departments
of Pediatrics and Medicine, Columbia University College
of Physicians and Surgeons, New York, NY, United States
Intramyocellular lipid (IMCL) droplets are dynamic
organelles whose morphology reflects their vital roles
in lipid synthesis, utilization and storage in muscle
energy metabolism. To develop non-invasive means to
measure droplet microstructure in vivo, we investigated
the molecular diffusion behavior of IMCL with diffusion
MR spectroscopy. Our results demonstrate the feasibility
of MR diffusion characterization of IMCL droplet
microstructure and provide evidence of the sensitivity
of this method to metabolic alterations. The use of
diffusion MR methodology in vivo promises to provide new
biophysical insights in the investigation of droplet
dynamics and lipid metabolism in both animal models and
human subjects. The diffusion MR results may help
contribute to an improved understanding and diagnosis of
obesity, diabetes and other metabolic disorders.
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