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Abstract #0042

A novel approach to tracer-kinetic modeling of (macromolecular) multi-bolus DCE-MRI data, applied in a murine tumor model

Igor Jacobs 1,2 , Gustav Strijkers 1,2 , Henk Keizer 3 , Henk Janssen 3 , Klaas Nicolay 1,2 , and Matthias Schabel 4

1 Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2 Center for Imaging Research and Education, Eindhoven, Netherlands, 3 SyMO-Chem BV, Eindhoven, Netherlands, 4 Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon, United States

Conventional low-molecular-weight DCE-MRI and tracer-kinetic modeling does not support separate estimates of blood flow and microvascular permeability, while this would be advantageous for accurate cancer treatment evaluation. In this research a multi-bolus DCE-MRI protocol was developed, in which contrast agents of various molecular weights were injected sequentially. A novel tracer-kinetic modeling approach, based on the two-compartment exchange model, was applied to simultaneously fit multi-bolus data. The feasibility of this approach was shown in a murine tumor model. Single-pixel multi-bolus curves were of good quality and significant differences in extraction fraction and washout rate constant were observed between the different contrast agents.

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