Abstract #0042
A novel approach to tracer-kinetic modeling of (macromolecular) multi-bolus DCE-MRI data, applied in a murine tumor model
Igor Jacobs 1,2 , Gustav Strijkers 1,2 , Henk Keizer 3 , Henk Janssen 3 , Klaas Nicolay 1,2 , and Matthias Schabel 4
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Center
for Imaging Research and Education, Eindhoven,
Netherlands,
3
SyMO-Chem
BV, Eindhoven, Netherlands,
4
Advanced
Imaging Research Center, Oregon Health and Science
University, Portland, Oregon, United States
Conventional low-molecular-weight DCE-MRI and
tracer-kinetic modeling does not support separate
estimates of blood flow and microvascular permeability,
while this would be advantageous for accurate cancer
treatment evaluation. In this research a multi-bolus DCE-MRI
protocol was developed, in which contrast agents of
various molecular weights were injected sequentially. A
novel tracer-kinetic modeling approach, based on the
two-compartment exchange model, was applied to
simultaneously fit multi-bolus data. The feasibility of
this approach was shown in a murine tumor model.
Single-pixel multi-bolus curves were of good quality and
significant differences in extraction fraction and
washout rate constant were observed between the
different contrast agents.
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