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Abstract #0043

Altered choline phospholipid metabolism in pancreatic cancer cells and tumor xenografts

Marie-France Penet* 1 , Tariq Shah* 1 , Santosh Bharti 1 , Yelena Mironchik 1 , Flonn Wildes 1 , Anirban Maitra 2 , and Zaver M. Bhujwalla 1

1 JHU ICMIC Program, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Pancreatic cancer is an aggressive disease usually advanced at the time of diagnosis. Biomarkers with sensitivity and specificity for early diagnosis are urgently needed. Here we have investigated the metabolism of a panel of pancreatic cell lines in vitro and in vivo. Using high-resolution 1H MRS we observed elevated choline-containing compounds, along with high levels of choline kinase. Total choline signal was detected in vivo in tumor xenografts, with the highest concentration in the Panc1 tumors. Our study showed that the altered choline phospholipid metabolism could be used for noninvasive detection of pancreatic cancer and for treatment strategies.

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