Abstract #0044
In vivo 1 H MRS detection of choline compounds in pancreas of MEN1 knock-out mice
Min-Hui Cui 1,2 , Ziqiang Yuan 3 , Sean Cahill 4 , Asha Adem 3 , Steven K. Libutti 3 , and Craig A. Branch 1,2
1
Gruss Magnetic Resonance Research Center,
Albert Einstein College of Medicine, Bronx, New York,
United States,
2
Radiology,
Albert Einstein College of Medicine, Bronx, New York,
United States,
3
Surgery,
Albert Einstein College of Medicine, Bronx, New York,
United States,
4
Biochemistry,
Albert Einstein College of Medicine, Bronx, New York,
United States
We have demonstrated that in vivo
1
H
MRS has a potential role in diagnosis of pancreatic
cancer, in a multiple endocrine neoplasia type 1 (MEN1)
conditional knock-out mouse model. Choline was detected
in Men1 KO mice via in vivo
1
H
MRS, but not in WT mice. The elevated total choline
levels in Men1 KO mice were mainly due to high levels of
phophocholine and glycerophosphocholine in pancreas
tissues. Our approach may provide additional beneficial
information in the context of pancreatic lesion
diagnosis and allow monitoring tumor responsiveness to
treatment.
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