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Abstract #0046

Multiparametric MRI mapping of oxygen delivery and hypoxia in renal 786-O-R murine xenografts

James PB O'Connor 1 , Yann Jamin 2 , Jessica KR Boult 2 , Muhammad Babur 3 , John C Waterton 1 , Damien McHugh 1 , Andrew R Reynolds 4 , Kaye J Williams 3 , Geoff JM Parker 1 , and Simon P Robinson 2

1 Imaging Sciences, University of Manchester, Manchester, Greater Manchester, United Kingdom, 2 Radiotherapy and Imaging, Institute of Cancer Research, Sutton, London, United Kingdom, 3 School of Pharmacy, University of Manchester, Manchester, Greater Manchester, United Kingdom, 4 Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Sutton, London, United Kingdom

T 1 weighted oxygen-enhanced MRI can measure oxygen delivery and hypoxia in tumors. We report the first study to combine this method with BOLD, DCE-MRI and immunohistochemistry. We show how combining these modalities provides fresh insight into the spatial and temporal oxygen handling of 786-O-R renal xenografts.

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