Abstract #0046
Multiparametric MRI mapping of oxygen delivery and hypoxia in renal 786-O-R murine xenografts
James PB O'Connor 1 , Yann Jamin 2 , Jessica KR Boult 2 , Muhammad Babur 3 , John C Waterton 1 , Damien McHugh 1 , Andrew R Reynolds 4 , Kaye J Williams 3 , Geoff JM Parker 1 , and Simon P Robinson 2
1
Imaging Sciences, University of Manchester,
Manchester, Greater Manchester, United Kingdom,
2
Radiotherapy
and Imaging, Institute of Cancer Research, Sutton,
London, United Kingdom,
3
School
of Pharmacy, University of Manchester, Manchester,
Greater Manchester, United Kingdom,
4
Breakthrough
Breast Cancer Research Centre, Institute of Cancer
Research, Sutton, London, United Kingdom
T
1
weighted oxygen-enhanced MRI can
measure oxygen delivery and hypoxia in tumors. We report
the first study to combine this method with BOLD, DCE-MRI
and immunohistochemistry. We show how combining these
modalities provides fresh insight into the spatial and
temporal oxygen handling of 786-O-R renal xenografts.
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