Abstract #0047

Is R1 of Lipids related to pO2? Lessons from two tumor models

Florence Colliez ¹ , Marie-Aline Neveu ¹ , Julie Magat ¹ , Thanh Trang Cao Pham ¹ , Bernard Gallez ¹ , and Bndicte F Jordan ¹

¹ Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium

Variations in T1 and T2* are potentially valuable MRI tools to follow changes in tumor oxygenation. T2* is sensitive to the relative Hb/HbO2 ratio in vessel, while T1 change is sensitive to dissolved oxygen which acts as a T1-shortening paramagnetic contrast agent. The aim of the current work is to investigate the quantitative aspect of a new oxygen mapping method: MOBILE. Two tumor models were submitted to (i) hyperoxic challenges induced by carbogen breathing and (ii) hypoxic challenges induced by Combetastatin A-4 Phosphate. Actual pO2 values were obtained by EPR oximetry and significantly correlated to Lipids R1 values.

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