Abstract #0048
Noninvasive MRI of tissue redox state based on endogenous chemical exchange saturation transfer (CEST) contrast
Kejia Cai 1,2 , He N Xu 1 , Anup Singh 1 , Lily Moon 1 , Mohammad Haris 1,3 , Xiaohong Joe Zhou 2 , Ravinder Reddy 1 , and Lin Z Li 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
CMRR
3T Research Program, Radiology, University of Illinois
at Chicago, Chicago, IL, United States,
3
Sidra
Medical and Research Center, Doha, Qatar
The disturbed balance of the redox state, such as
excessive oxidative stress, can lead to many pathologic
changes including cancer, heart diseases,
neurodegenerative diseases, and diabetes. Imaging
biomarkers for oxidative stress are a key research area.
The purpose of this study is to develop a non-invasive
MR imaging method for mapping the tissue redox state
based on the endogenous Chemical Exchange Saturation
Transfer (CEST) contrast. We report herein a CEST MRI
technique, together with correlations to optical redox
scanning to characterize tumor redox heterogeneity. The
mechanism on such correlation has also been
investigated.
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