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Abstract #0048

Noninvasive MRI of tissue redox state based on endogenous chemical exchange saturation transfer (CEST) contrast

Kejia Cai 1,2 , He N Xu 1 , Anup Singh 1 , Lily Moon 1 , Mohammad Haris 1,3 , Xiaohong Joe Zhou 2 , Ravinder Reddy 1 , and Lin Z Li 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 CMRR 3T Research Program, Radiology, University of Illinois at Chicago, Chicago, IL, United States, 3 Sidra Medical and Research Center, Doha, Qatar

The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative diseases, and diabetes. Imaging biomarkers for oxidative stress are a key research area. The purpose of this study is to develop a non-invasive MR imaging method for mapping the tissue redox state based on the endogenous Chemical Exchange Saturation Transfer (CEST) contrast. We report herein a CEST MRI technique, together with correlations to optical redox scanning to characterize tumor redox heterogeneity. The mechanism on such correlation has also been investigated.

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