Abstract #0050
Measuring Tumor Metabolism in Diffuse Intrinsic Pontine Gliomas (DIPG) Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging
Ilwoo Park 1 , Rintaro Hashizume 2 , Peder EZ Larson 1 , C. David James 2 , Daniel B Vigneron 1,3 , and Sarah J Nelson 1,3
1
Department of Radiology and Biomedical
Imaging, University of California San Francisco, San
Francisco, CA, United States,
2
Department
of Neurological Surgery, University of California San
Francisco, San Francisco, CA, United States,
3
Department
of Bioengineering and Therapeutic Sciences, University
of California San Francisco, San Francisco, CA, United
States
Diffuse intrinsic pontine gliomas (DIPGs) are one of the
most difficult pediatric cancers to treat. The methods
for assessing treatment response and tumor progression
are based on radiographic response but conventional MRI
is not sufficient for predicting clinical outcome. We
have demonstrated the feasibility of using
hyperpolarized
13
C
metabolic imaging to evaluate in vivo metabolism in
orthotopic brainstem xenografts injected with human DIPG
cells. The results suggest that this technique may
provide a unique non-invasive imaging tool that is able
to differentiate between different tissue pathologies
and aid in the management of patients with DIPG.
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