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Abstract #0050

Measuring Tumor Metabolism in Diffuse Intrinsic Pontine Gliomas (DIPG) Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging

Ilwoo Park 1 , Rintaro Hashizume 2 , Peder EZ Larson 1 , C. David James 2 , Daniel B Vigneron 1,3 , and Sarah J Nelson 1,3

1 Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2 Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 3 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

Diffuse intrinsic pontine gliomas (DIPGs) are one of the most difficult pediatric cancers to treat. The methods for assessing treatment response and tumor progression are based on radiographic response but conventional MRI is not sufficient for predicting clinical outcome. We have demonstrated the feasibility of using hyperpolarized 13 C metabolic imaging to evaluate in vivo metabolism in orthotopic brainstem xenografts injected with human DIPG cells. The results suggest that this technique may provide a unique non-invasive imaging tool that is able to differentiate between different tissue pathologies and aid in the management of patients with DIPG.

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