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Abstract #0055

Derivation and Evaluation of Amygdalo-Prefrontal Connections in Humans and Monkeys Using Diffusion Tractography

Longchuan Li 1 , Xiaoping Hu 2 , Jocelyne Bachevalier 3 , Warren Jones 1 , Sarah Shultz 1 , and Ami Klin 1

1 Department of Pediatrics, Marcus Autism Center, Children's HealthCare of Atlanta, Emory University, Atlanta, GA, United States, 2 Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, United States, 3 Yerkes National Primate Research, Emory University, GA, United States

Amygdala-cortical connections consist of major regions of social brain and mapping such a network may be critically informative of its roles in autism. In this study, diffusion tractography was used to delineate the connections between the amygdala and the prefrontal areas in macaque monkeys and humans. The results in monkeys were compared with the tracer literature and were also compared with those in humans. We found a generally similar pattern of connections between the tracer and tractography studies and between two species. Such work serves as the first step in realistically mapping amygdala network for the neural underpinnings of autism.

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