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Abstract #0056

Multi-centre reproducibility of diffusion MRI parameters for clinical sequences in the brain

Matthew Grech-Sollars 1 , Patrick W Hales 1 , Keiko Miyazaki 2 , Felix Raschke 3 , Daniel Rodriguez 4,5 , Martin Wilson 6 , Simrandip K Gill 6 , Tina Banks 7 , Dawn E Saunders 7 , Jonathan D Clayden 1 , Matt Gwilliam 2 , Thomas R Barrick 3 , Paul S Morgan 4,5 , Nigel P Davies 8 , James Rossiter 9 , Dorothee P Auer 4,5 , Richard Grundy 5 , Martin O Leach 2 , Franklyn A Howe 3 , Andrew C Peet 6 , and Chris A Clark 1

1 UCL Institute of Child Health, University College London, London, London, United Kingdom, 2 CR UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Foundation Trust, Surrey, United Kingdom, 3 Division of Clinical Sciences, St George's, University of London, London, United Kingdom, 4 Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom, 5 The Childrens Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom, 6 School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, 7 Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom, 8 Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 9 Electrical & Computer Engineering, University of Birmingham, Birmingham, United Kingdom

The reproducibility of diffusion MRI parameters, and more specifically the apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters the diffusion coefficient (D) and perfusion fraction (f), and diffusion tensor imaging (DTI) parameters mean diffusivity (MD) and fractional anisotropy (FA), was analysed across multiple centres using standard clinical protocols. ADC, D, MD and FA were found to have a good reproducibility and research studies can benefit from incorporating multi-centre data without any loss of reproducibility compared to what would be achieved from a single scanner at a single site.

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