Regional Metabolism During Healthy Aging in Mice Brain: A 1 H-[ 13 C]-NMR Study

Despite key role of neurotransmitters in brain function, brain energy metabolism has not been explored during healthy aging. In this study, we have investigated neuronal and astroglial metabolism in the cerebral cortex, hippocampus and striatum of adult and aged C57BL6 mice by using ¹ H-[ ¹³ C]-NMR spectroscopy together with infusion of ¹³ C labeled substrates. The ¹³ C turnover of amino acids was analyzed using a three compartment metabolic model to derive the metabolic rates. Aging is associated with an increased in astroglial flux and decrease in glutamatergic and GABAergic rates across different brain regions.

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