Abstract #0063
Manganese Induced Changes In Thalamic GABA Levels Influence Cognitive and Motor Performance
Ruoyun Ma 1,2 , Ann-Kathrin Stock 3 , S.Elizabeth Zauber 4 , James B. Murdoch 5 , Shalmali Dharmadhikari 1,2 , Zaiyang Long 1,2 , Christian Beste 3 , and Ulrike Dydak 1,2
1
School of Health Sciences, Purdue
University, West Lafayette, IN, United States,
2
Department
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, IN, United States,
3
Cognitive
Neurophysiology Department of Child and Adolescent
Psychiatry, Technical University Dresden, Dresden,
Germany,
4
Department
of Neurology, Indiana University School of Medicine,
Indianapolis, IN, United States,
5
Toshiba
Medical Research Institute USA, Mayfield Village, OH,
United States
Chronic occupational exposure to Manganese (Mn) has been
associated with cognitive and motor disorders similar to
Parkinson disease. Based on a previous observation of
elevated GABA levels in Mn-exposed workers, this study
investigates the connection between thalamic GABA levels
measured by MRS, motor function, and behavior measures
of action control and inhibition in typical US welders.
The significant correlations between these measures
indicate that GABA may serve as biomarker for early
diagnosis of Mn-induced neurotoxicity.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
