Meeting Banner
Abstract #0063

Manganese Induced Changes In Thalamic GABA Levels Influence Cognitive and Motor Performance

Ruoyun Ma 1,2 , Ann-Kathrin Stock 3 , S.Elizabeth Zauber 4 , James B. Murdoch 5 , Shalmali Dharmadhikari 1,2 , Zaiyang Long 1,2 , Christian Beste 3 , and Ulrike Dydak 1,2

1 School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2 Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3 Cognitive Neurophysiology Department of Child and Adolescent Psychiatry, Technical University Dresden, Dresden, Germany, 4 Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States, 5 Toshiba Medical Research Institute USA, Mayfield Village, OH, United States

Chronic occupational exposure to Manganese (Mn) has been associated with cognitive and motor disorders similar to Parkinson disease. Based on a previous observation of elevated GABA levels in Mn-exposed workers, this study investigates the connection between thalamic GABA levels measured by MRS, motor function, and behavior measures of action control and inhibition in typical US welders. The significant correlations between these measures indicate that GABA may serve as biomarker for early diagnosis of Mn-induced neurotoxicity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here