Manganese Induced Changes In Thalamic GABA Levels Influence Cognitive and Motor Performance
Ruoyun Ma 1,2 , Ann-Kathrin Stock 3 , S.Elizabeth Zauber 4 , James B. Murdoch 5 , Shalmali Dharmadhikari 1,2 , Zaiyang Long 1,2 , Christian Beste 3 , and Ulrike Dydak 1,2
School of Health Sciences, Purdue
University, West Lafayette, IN, United States,
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, IN, United States,
Neurophysiology Department of Child and Adolescent
Psychiatry, Technical University Dresden, Dresden,
of Neurology, Indiana University School of Medicine,
Indianapolis, IN, United States,
Medical Research Institute USA, Mayfield Village, OH,
Chronic occupational exposure to Manganese (Mn) has been
associated with cognitive and motor disorders similar to
Parkinson disease. Based on a previous observation of
elevated GABA levels in Mn-exposed workers, this study
investigates the connection between thalamic GABA levels
measured by MRS, motor function, and behavior measures
of action control and inhibition in typical US welders.
The significant correlations between these measures
indicate that GABA may serve as biomarker for early
diagnosis of Mn-induced neurotoxicity.
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