Detection of cerebral NAD + by in vivo 1 H NMR spectroscopy

Nicotinamide adenine dinucleotide (NAD+) has a central role in cellular metabolism and energy production and is related to gene expression, calcium mobilization, aging, cell death and timing of metabolism via the circadian rhythm. The in vivo detection of NAD+ has been limited and has only recently become feasible with high-field 31P NMR spectroscopy. Here 1H NMR spectroscopy is presented as a simple, but robust alternative for the in vivo detection of NAD+. Special attention is given to the interaction between NAD+ and water magnetization. Perturbation of the water protons should be minimized to ensure full NAD+ signal detection efficiency.

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