Assessment of Macromolecular and Metabolic Alterations during Normal Brain Aging in the Dark Agouti Rat using 1H MRS at 17.2 Tesla

Normal brain aging is usually associated with a decline in brain function. Yet, the neural basis of age-related cognitive dysfunction in normal brain aging remains to be entirely elucidated. In this study, we sought to explore further these metabolic alterations in the brain of healthy rats with in vivo short echo time ¹ H MRS at 17.2 T. Comparing metabolic profiles from young and elderly rats (1 and 16 months old respectively), it was found a decrease in neurotransmitters (Gln+Glu, GABA) and increase in Ins and tCho consistent with decline of neural function and chronic low-level glial activation consistent with previous observations in humans.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.