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Abstract #0077

Concurrent ASL and BOLD FMRI of Working Memory in Typically Developing Population

Lirong Yan 1 , Emily Kilroy 2 , Mayank Jog 1 , and Danny JJ Wang 1

1 University of California Los Angeles, Los Angeles, CA, United States, 2 University of Southern California, Los Angeles, CA, United States

Due to the lack of assays of baseline function and absolute quantification of task-induced effect size, it is hard to interpret developmental BOLD fMRI findings. In this study, a concurrent ASL/BOLD fMRI paradigm of working memory tasks was employed to investigate the relationship between CBF and BOLD responses in 57 children and adolescents aged 7 to 17. Our results showed that while the percentage of BOLD response increases with age, both baseline CBF and absolute task-induced CBF decrease with age, suggesting more efficient use of oxygen of the brain during development.

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