Concurrent ASL and BOLD FMRI of Working Memory in Typically Developing Population
Lirong Yan 1 , Emily Kilroy 2 , Mayank Jog 1 , and Danny JJ Wang 1
University of California Los Angeles, Los
Angeles, CA, United States,
of Southern California, Los Angeles, CA, United States
Due to the lack of assays of baseline function and
absolute quantification of task-induced effect size, it
is hard to interpret developmental BOLD fMRI findings.
In this study, a concurrent ASL/BOLD fMRI paradigm of
working memory tasks was employed to investigate the
relationship between CBF and BOLD responses in 57
children and adolescents aged 7 to 17. Our results
showed that while the percentage of BOLD response
increases with age, both baseline CBF and absolute
task-induced CBF decrease with age, suggesting more
efficient use of oxygen of the brain during development.
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