Age-dependent diffusion and perfusion normal values in gray matter brain structures in children

The extraction of diffusion and perfusion parameters from MRI is of high clinical utility in various neurological diseases. However, adult normal values cannot be applied directly to pediatric patients due to age-dependent parameter changes. The aim of this work is to investigate the age-dependent change of ADC and CBF values in healthy children over the entire pediatric age range by applying an atlas-based analysis of ASL and ADC datasets in different brain regions. Overall, logarithmic relations between age and ADC as well as CBF values were found, which may help to identify neuropathological conditions of childhood in future.

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