Cortical maturation in the preterm period revealed using a multi-component diffusion-weighted MR model.
Zach Eaton-Rosen 1 , Andrew Melbourne 1 , Eliza Orasanu 1 , Alan Bainbridge 2 , Giles S. Kendall 3 , Nicola J. Robertson 3 , Neil Marlow 3 , and Sebastien Ourselin 1
CMIC, UCL, London, United Kingdom,
Physics, UCH, London, United Kingdom,
Neonatology, EGA UCL Institute for Women's Health,
London, United Kingdom
During normal cortical development, there is a period of
high fractional anisotropy (FA) measured in the cortex
as revealed by diffusion tensor imaging. In a
longitudinal study of a preterm neonatal population, we
fitted the NODDI model to multi-shell diffusion MR and
separated the FA into contributions from orientation
dispersion (ODI) and from the volume fraction of the
intra-cellular component (vic). We found that the
decrease in FA is predominantly attributable to
increased ODI rather than changing vic. Establishing
biomarkers of cortical maturation from
diffusion-weighted data will aid in developing measures
of cognitive outcome in this at-risk population.
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