Abstract #0099
In vivo estimation of axon diameter in the human spinal cord using 300 mT/m gradients
Tanguy Duval 1 , Jennifer A. McNab 2 , Kawin Setsompop 3 , Thomas Witzel 3 , Torben Schneider 4 , Susie Yi Huang 2 , Boris Keil 3 , Eric Klawiter 3 , Lawrence L. Wald 3 , and Julien Cohen-Adad 1
1
Institute of Biomedical Engineering,
Polytechnique Montreal, Montreal, Quebec, Canada,
2
Department
of Radiology, Stanford University, Stanford, California,
United States,
3
A.A.
Martinos Center for Biomedical Imaging, Massachusetts
General Hospital, Harvard Medical School, Charlestown,
Massachusetts, United States,
4
NMR
Research Unit, Department of Neuroinflammation, Queen
Square MS Centre, UCL Institute of Neurology, London,
London, United Kingdom
Composite hindered and restricted model of diffusion was
shown to retrieve white matter micro-structural
information, such as axon diameter. Using a dedicated
human gradient system that can achieve 300 mT/m, we
produced the first in vivo mapping of axon diameter in
the human spinal cord. State-of-the-art methods were
deployed to overcome the numerous artifacts associated
with spinal cord imaging. Maps of axon diameter were
generated for each patient, and diffeomorphic
registration on a white-matter template yielded an
average atlas of axon diameter. Qualitative comparison
with histological data on a rat suggests consistent
trends of axon diameter across specific spinal pathways.
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