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Abstract #0100

A combined acquisition of T 1 and AxCaliber can link between axon diameter and myelination

Daniel Barazany 1,2 , Derek K Jones 2 , and Yaniv Assaf 1

1 Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, 2 CUBRIC School of Psychology, Cardiff University, Cardiff, United Kingdom

AxCaliber is a diffusion MRI method that models the axon diameter distribution. here we introduce a noval acquisition that Combines T1 and AxCaliber to provide further insight into white matter micro-structure as it links between axons at different size and their T1. This kind of combined acquisition and analysis allows to estimate the effect of myelin content on T1 and its relation to axon diameter. The results of this work demonstrate that MRI allows to probe white matter tissue micro-structure providing invaluable high details that so far could be extracted only by invasive techniques.

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