On the use of the two-pool model to improve the accuracy of axon calibration

We here propose to study the reason for the systematic overestimation of the smaller radius in available axon diameter mapping techniques when a simple cylinder model is used for the axon. Recent studies have introduced an alternative model, assuming that water molecules close to the axon membranes have a slow diffusivity while those far from the membranes are characterized by a fast diffusivity, yielding the two-pool cylinder model. This study shows how attenuations from this model when varying the thickness of the layer close to axonal membranes can be similar to attenuations from the simple cylinder model with higher radius for small radii.

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