Abstract #0110
High-resolution 3D diffusion MRI: detection of lipid-rich necrotic core in plaques without contrast media
Yibin Xie 1,2 , Wei Yu 3 , Zhaoyang Fan 1 , Christopher Nguyen 1,2 , Jing An 4 , Zhaoqi Zhang 3 , and Debiao Li 1,2
1
Cedars-Sinai Medical Center, Los Angeles,
California, United States,
2
University
of California, Los Angeles, Los Angeles, California,
United States,
3
Anzhen Hospital, Beijing,
China,
4
Siemens
Healthcare, Beijing, China
Diffusion MRI has shown great promises for the detection
of lipid-rich necrotic core (LRNC) with excellent image
contrast. However current 2D EPI-based methods suffer
from poor image quality due to susceptibility-induced
artifacts and limited resolution for imaging fine
anatomy in plaques. A novel diffusion weighted 3D
sequence is developed in this work with features
including motion compensation and dark blood. High
resolution 3D carotid vessel wall images with excellent
image quality were acquired for the first time.
Significantly lower ADC values were observed in LRNC
than fibrous plaque tissue and normal vessel wall. This
technique could be used to detect lipid-rich necrotic
core in carotid plaque in vivo without the use of
contrast agents.
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