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Abstract #0110

High-resolution 3D diffusion MRI: detection of lipid-rich necrotic core in plaques without contrast media

Yibin Xie 1,2 , Wei Yu 3 , Zhaoyang Fan 1 , Christopher Nguyen 1,2 , Jing An 4 , Zhaoqi Zhang 3 , and Debiao Li 1,2

1 Cedars-Sinai Medical Center, Los Angeles, California, United States, 2 University of California, Los Angeles, Los Angeles, California, United States, 3 Anzhen Hospital, Beijing, China, 4 Siemens Healthcare, Beijing, China

Diffusion MRI has shown great promises for the detection of lipid-rich necrotic core (LRNC) with excellent image contrast. However current 2D EPI-based methods suffer from poor image quality due to susceptibility-induced artifacts and limited resolution for imaging fine anatomy in plaques. A novel diffusion weighted 3D sequence is developed in this work with features including motion compensation and dark blood. High resolution 3D carotid vessel wall images with excellent image quality were acquired for the first time. Significantly lower ADC values were observed in LRNC than fibrous plaque tissue and normal vessel wall. This technique could be used to detect lipid-rich necrotic core in carotid plaque in vivo without the use of contrast agents.

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