Abstract #0111
In vivo quantification of lipid-rich necrotic core using contrast-enhanced three-dimensional vessel wall imaging
Jie Sun 1 , Niranjan Balu 1 , Kiyofumi Yamada 1 , Jinnan Wang 2 , Daniel S. Hippe 1 , Dongxiang Xu 1 , Thomas S. Hatsukami 1 , and Chun Yuan 1
1
University of Washington, Seattle, WA,
United States,
2
Philips
Research North America, Briarcliff Manor, NY, United
States
In vivo quantification of lipid-rich necrotic core size
not only reveals prognostic information on patients
atherothrombotic risk, but also provides a novel means
for understanding effects of risk factors on plaque
progression. Although a 2D multi-contrast protocol is
traditionally used for classifying LRNC areas in
advanced plaques, recently developed 3D sequences offer
the opportunity to move LRNC quantification from 2D to
3D. This report represents one of the first studies to
evaluate the performance of 3D MRI with
contrast-enhanced imaging in delineating LRNC areas,
which showed good agreement with a histologically
validated 2D multi-contrast protocol across various
lesion complexities.
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