Monitoring vascular permeability and remodelling following endothelial injury in a murine model using an MR albumin binding contrast agent

Endothelial cells play a critical role in maintaining vascular homeostasis. However, vascular damage may lead to endothelial dysfunction characterized by decreased bioavailability of nitric oxide, a signalling molecule involved in vasodilatation, with several anti-atherogenic and anti-inflammatory properties. Previous studies have shown that contrast enhanced MRI using gadofosveset, an albumin binding gadolinium contrast agent, can detect endothelial damage, angiogenesis and vascular permeability in different animal models. In this study, we explored whether imaging with gadofosveset could be used to monitor endothelial cell recovery, permeability and vessel wall remodelling in a murine model of aortic endothelial denudation.

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