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Abstract #0118

A Combined High Spatial- and High Angular-Resolution Diffusion MRI Atlas of the Human Brainstem and Thalamus

Evan Calabrese 1 , Christine Hulette 2 , and G. Allan Johnson 3

1 Biomedical Engineering, Duke University, Durham, North Carolina, United States, 2 Pathology, Duke University, Durham, North Carolina, United States, 3 Radiology, Duke University, Durham, North Carolina, United States

Deep brain stimulation (DBS) provides symptomatic relief from a number of otherwise refractory neurologic conditions through stimulation of small structures in the brainstem and diencephalon. As researchers and clinicians continue to investigate new DBS targets, there is a need for accurate 3D maps of brainstem anatomy and structural connectivity. Diffusion MRI can provide important insight, but clinical studies lack the spatial and/or angular (diffusion) resolution needed for detailed mapping. We present a high spatial- and high angular-resolution diffusion MRI atlas of the postmortem human brainstem and thalamus with an emphasis on structural mapping of DBS targets.

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