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Abstract #0120

Multiple Echo and Inversion Time MPRAGE with Inner Loop GRAPPA Acceleration and Prospective Motion Correction for Minimally Distorted Multispectral Brain Morphometry

Andre J. W. van der Kouwe 1 , M. Dylan Tisdall 1 , Himanshu Bhat 2 , Bruce Fischl 1 , and Jonathan R. Polimeni 1

1 Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2 Siemens Healthcare USA, Charlestown, MA, United States

Conventional MPRAGE suffers from blurring in the inner phase encoding direction (between inversions) and readout direction, due to T1 and T2* decay that broadens the point spread functions in these directions, respectively. This can be mitigated by combining multiple GRAPPA accelerated phase encoding blocks and multiple higher bandwidth echoes (shorter readouts that also reduce susceptibility distortion), respectively. This also enables estimation of absolute T1 and T2* times for each voxel. To minimize blurring, real-time prospective motion tracking with EPI volume navigators is included. The resulting generalized MPRAGE sequence provides high quality images for brain morphometry without affecting total acquisition time.

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