Quantitative properties (water content, relaxometry, MT) of the post mortem brain: a baseline for normal tissue

MRI of fixed tissue is increasingly used to investigate the brain. However, properties of tissue change with fixation. This study investigates post mortem formalin-fixed brains quantitatively in order to provide a baseline for MR parameters characteristic of healthy brain tissue. The variability of several quantitative MRI parameters is characterized in fixed brain tissue obtained from donors unaffected by neurological conditions. Among other parameters, quantitative water content determined non-invasively with MRI is reported on whole human post mortem brains for the first time to our knowledge. Correlations between different parameters were investigated and compared to the same quantities measured in vivo.

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