Arterial spin labeling perfusion MRI in neonates with hypoxic-ischemic encephalopathy.
Jill B. De Vis 1 , Jeroen Hendrikse 1 , Esben T. Petersen 1 , Linda S. de Vries 2 , Frank van Bel 2 , Thomas Alderliesten 2 , Floris Groenendaal 2 , and Manon J.N.L. Benders 2
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Utrecht,
Hypoxic-ischemic injury in neonates can cause impaired
autoregulation of the cerebral vasculature resulting in
hyperperfusion of brain tissue and probably secondary
injury. In this study we investigated whether
hyperperfusion, evaluated with arterial spin labeling MR
imaging is associated with an adverse outcome in
neonates with hypoxic-ischemic encephalopathy. We found
higher perfusion in the basal ganglia and thalami of
neonates with adverse compared to favorable outcome (69
27 versus 31 10 ml/100g/min, p < 0.01).
Hyperperfusion in the basal ganglia and thalami had a
sensitivity of 86% and a specificity of 100% for the
prediction of adverse outcome.
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