Abstract #0132
Imaging the developing brain at the bedside: A comparison of diffuse optical tomography and functional MRI
Silvina L. Ferradal 1 , Steve M. Liao 2 , Adam T. Eggebrecht 1 , Joshua S. Shimony 1 , Terrie E. Inder 3 , Joseph P. Culver 1 , and Christopher D. Smyser 2
1
Radiology, Washington University in St.
Louis, St. Louis, MO, United States,
2
Pediatrics,
Washington University in St. Louis, St. Louis, MO,
United States,
3
Harvard Medical School,
Boston, MA, United States
Adverse neurodevelopmental outcomes in preterm infants
remain a clinical challenge. While functional
connectivity (fc) using functional MRI opens a window to
study brain function in neonates, frequent longitudinal
monitoring is often restricted in the sickest infants.
Diffuse optical tomography (DOT) provides a portable
alternative modality for evaluating brain function at
the bedside. Here we demonstrate that our DOT system
generates resting-state maps exhibiting strong agreement
with non-concurrent fcMRI maps in identical subjects.
Our results suggest that fcDOT provides satisfactory
spatial localization and resolution, and illustrates its
potential as a viable imaging tool for bedside
monitoring.
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