Abstract #0137
Hyperpolarized [1,3- 13 C 2 ]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer.
Sonia Colombo Serra 1 , Pernille Rose Jensen 2 , Luigi Miragoli 1 , Magnus Karlsson 2 , Claudia Cabella 1 , Luisa Poggi 1 , Luca Venturi 3 , Fabio Tedoldi 1 , and Mathilde Lerche 2
1
Centro Ricerche Bracco, Bracco Imaging SpA,
Colleretto Giacosa, Torino, Italy,
2
Albeda
Research, Copenhagen, Copenhagen, Denmark,
3
CEIP,
University of Torino, Colleretto Giacosa, Torino, Italy
Hepatocellular carcinoma (HCC) is most often found in
cirrhotic livers and can be hardly diagnosed relying on
anatomical information alone. Magnetic resonance is
commonly used to identify anatomical lesions, but can
also provide information on cellular metabolism by an
emerging method that uses
13
C
labeled hyperpolarized molecules. This study aimed at
probing the potential of hyperpolarized [1,3-
13
C
2
]ethyl
acetoacetate as a metabolic marker of HCC. A liver
cancer implanted in rats is diagnosed due to a higher
substrate-to-product ratio in tumors than in healthy
livers demonstrating that the metabolism of the liver
isoform of carboxyl esterase can be monitored
in
vivo
.
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