Assessment of cholinergic synaptic transmission modulation in the mouse brain using resting-state functional Magnetic Resonance Imaging (rsfMRI)

We hypothesize that synaptic transmission deficits in neurodegenerative disorders (ND) could be reflected as altered brain functional connectivity (FC) and can be detected using resting-state fMRI (rsfMRI). We investigate this hypothesis by pharmacologically modulating cholinergic synaptic transmission in the mouse brain using scopolamine and milameline. Scopolamine induced a decrease of FC between the hippocampus and thalamus and the hippocampus bilaterally, connections involved in learning/memory. The scopolamine-induced FC deficits are reversed by milameline. These results have implications for studies in animal models of ND, where rsfMRI can be used as a non-invasive tool to detect the modulation of synaptic transmission.

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