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Abstract #0161

Functional connectivity of consolidated memory circuits in rabbit after trace eyeblink conditioning

Matthew P Schroeder 1 , Craig Weiss 1 , Daniel Procissi 2 , and John F Disterhoft 1

1 Physiology, Northwestern University, Chicago, IL Illinois, United States, 2 Radiology, Northwestern University, Chicago, IL Illinois, United States

Memory acquisition initially depends on the hippocampus but long-term memory resides in a distributed cortical network. This study characterized functional connectivity changes at sites mediating long-term memory. New Zealand White rabbits underwent trace eyeblink conditioning for ten days. Resting state scans were acquired following each session in a 7T Bruker MRI. Rabbits demonstrated greater hippocampal connectivity with HVI cerebellum, perirhinal cortex and thalamus and greater prefrontal connectivity with cholinergic basal forebrain after conditioning. Connectivity gradually and significantly changed as a result of learning a forebrain-dependent task. Future studies may identify additional regions showing connectivity changes as a result of learning.

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