Abstract #0168
DMN FUNCTIONAL CONNECTIVITY CHANGES PREVIOUS TO CLINICAL DIAGNOSIS OF ALZHEIMER'S DISEASE
Eva Manzanedo 1 , Alexandra Cristobal 1 , Daniel Garca Frank 1 , Elena Molina Molina 2 , Ana Beatriz Solana 2,3 , Norberto Malpica 1 , Juan lvarez-Linera 4 , and Juan Antonio Hernndez Tamames 2,4
1
Universidad Rey Juan Carlos, Mstoles,
Madrid, Spain,
2
CTB,
Madrid, Spain,
3
General
Electric, Munich, Germany,
4
Fundacin
Reina Sofa, Madrid, Spain
DMN functional connectivity differences between healthy
subjects with significantly different normalized
hippocampal volume (NHV) are analyzed in this work. Two
groups of 25 subjects have been extracted out of the 632
subjects based on the NHV. A connectivity decrease in
the DMN is statistically significant in the group of
subjects with lower NHV. Considering that these subjects
are more prone to develop AD, we have corroborated that
DMN functional changes are an early biomarker for AD,
which happen at the same time as structural changes, or
maybe even before, because no structural changes in DMN
areas have been appraised yet.
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