Abstract #0169
Changes in Anatomical and Functional Connectivity Related to Lower Hippocampal Volume
Jos Angel Pineda Pardo 1,2 , Miguel Molina 2 , Alexandra Cristobal 2 , Eva Manzanedo 2 , Francisco del Pozo 1 , Juan lvarez-Linera 2 , and Juan Antonio Hernndez-Tamames 2
1
Laboratory of Neuroimaging, Center for
Biomedical Technology, Pozuelo de Alarcn, Madrid,
Spain,
2
Laboratory
of Neuroimaging, Fundacin CIEN-Fundacin Reina Sofa,
Madrid, Madrid, Spain
Hippocampal atrophy is an early biomarker of
Alzheimer's. According to this, we defined two groups of
healthy elderly subjects with a normalized hippocampal
volume (NHV) located at the top and bottom of the
population distribution. We built structural networks
using deterministic tractography and functional networks
through fMRI correlations. The networks were compared
between groups using a Wilcoxon test. In the higher NHV
group we found higher anatomical connections between
hippocampus and temporal cortices, and lower functional
connections between entorhinal and cingulate cortices.
The lower SC might be representative of an upcoming
neurodegenerative process, being the higher FC a
compensatory mechanism.
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