Abstract #0170
Disrupted intra- and extra- amygdaloid effective connectivity in presence of early life stress
Karthik R Sreenivasan 1 , Merida M Grant 2 , Kimberly H Wood 3 , Muriah Wheelock 3 , Joshua R Shumen 3 , Richard C Shelton 2 , David C Knight 3 , and Gopikrishna Deshpande 1,4
1
AU MRI Research Center, Department of
Electrical and Computer Engineering, Auburn University,
Auburn, AL, United States,
2
Department
of Psychiatry and Behavioral Neurobiology, The
University of Alabama at Birmingham, Birmingham, AL,
United States,
3
Department
of Psychology, The University of Alabama at Birmingham,
Birmingham, AL, United States,
4
Department
of Psychology, Auburn University, Auburn, AL, United
States
Although we know that presence of early life stress (ELS)
modulates amygdala activity, it is unclear if the
amygdala connectivity is affected and which amygdala
nuclei cause these differences. In this study we perform
effective connectivity analysis of fMRI data obtained
from healthy controls with and without history of ELS.
The analysis showed increased connectivity from right
central nucleus and also enhanced amygdala connectivity
in participants exposed to ELS. Our results showed
intra- and extra- amygdaloid connectivity disruptions in
the presence of ELS which could play a major role in
understanding disorders caused by altered fear
circuitry.
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