Manganese(II)-Block Copolymer Complexes and Their Use for MRI of Biological Processes
Nikorn Pothayee 1 , Der-Yow Chen 1 , Maria Aronovo 2 , Chunqi Qian 1 , Richard Leapman 2 , and Alan Koretsky 1
Laboratory of Functional and Molecular
Imaging, NINDS, NIH, Bethesda, MD, United States,
of Cellular Imaging and Macromolecular Biophysics, NIBIB,
NIH, Bethesda, MD, United States
In this work,we describe a one-pot and aqueous-based
preparation of paramagnetic metal ion-block copolymer
complexes for potential use as MRIcontrast agent. The
pH-sensitive nature of soft particles was exploited in
response to neuronal uptake and subsequent transport of
Mn ions, which can be visualized by MRI.
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