Abstract #0193
Targeted MRI In Vivo by Hyperpolarized Silicon Nanoparticles
Jingzhe Hu 1 , Maja Cassidy 2 , Nicholas Whiting 1 , Pamela Constantinou 3 , Niki Zacharias Millward 1 , David Volk 4 , David Gorenstein 4 , Daniel Carson 3 , Charles Marcus 5 , and Pratip Bhattacharya 1
1
Cancer Systems Imaging, The University of
Texas, MD Anderson Cancer Center, Houston, TX, United
States,
2
Kavli
Institute of Nanoscience, Delft University of
Technology, Delft, Netherlands,
3
Biochemistry
and Cell Biology, Rice University, Houston, TX, United
States,
4
Institute
of Molecular Medicine and Department of NanoMedicine and
Biomedical Engineering, The University of Texas Health
Science Center at Houston, Houston, TX, United States,
5
Center
for Quantum Devices, Niels Bohr Institute, University of
Copenhagen, Copenhagen, Denmark
Nanomedicine is an emerging field that offers great
promise in the development of non-invasive strategies
for the diagnosis and treatment of disease.
Hyperpolarized silicon nanoparticles are one such
material that has emerged as a platform technology for
targeting that may suit a wide range of potential
applications. They can be easily surface functionalized,
are biocompatible and biodegradable and has opened up
the possibility of performing in vivo targeted MRI in
real time with over 10,000 fold sensitivity enhancement
via dynamic nuclear polarization (DNP).
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